Ethnic Differences in Alzheimer's Disease Survival and Pathology 

 
   Lead Investigator:    Kala Mehta
   Institution      :    UC San Francisco
   E-Mail           :    Kala.Mehta@ucsf.edu
   Proposal ID      :    374


   Publications:


1  Mehta K,  Kurland B , Barnes D, Yaffe K, Miller B, Perez-Stable EJ
   African American and Latino AD Patients have longer survival than white AD patients: data from the National Alzheimer's Coordinating Center datasets
   2006   Abstract  National Meeting of the Resource Center for Minority Aging Research , 

   ACCEPTED



2  Mehta KM,  Kurland B , Barnes D, Yaffe K, Perez-Stable E, Miller B
   African American and Latino Alzheimer's disease patient's have longer survival than white Alzheimer's disease patients: Data from the National Alzheimer's Coordinating Center datasets
   Abstract  Neurology,66:A218,2006,

   PUBLISHED



3  Mehta KM, Yaffe K, Perez-Stable EJ, Stewart A, Barnes D,  Kurland BF , Miller BL
   Race/ethnic differences in AD survival in US Alzheimer's Disease Centers
   Journal Article  Neurology,70:1163-1170,2008,PMC2830859

   PUBLISHED



4  Ontaneda D, Mehta KM, Perez-Stable E
   Race/ethnic differences in AD survival in us Alzheimer's disease centers
   Journal Article  Neurology,72:1620,2009,

   PUBLISHED





   Proposal Description:
   Addressing the needs of diverse older adults with dementia is a public health issue of increasing importance as over three million dementia patients will be of minority ethnicity by 2050. A growing literature substantiates that minority older adults have higher rates of dementia. However little is known about survival and neuropathological characteristics in these ethnically-diverse adults. As Alzheimer???s disease (AD) is the most common form of dementia, this proposal will examine if a difference in survival exists for AD patients of minority ethnicity as compared to White AD patients. If a difference is found, we will seek to understand the role that demographics and markers of   severity have on this relationship. Secondly, we will evaluate if there are differences in neuropathology between minority and White AD patients. This research will be conducted in four race/ethnic groups, three minority groups [African American (AA), Latino (L), Asian (A)] as compared to White (W) patients. We will test our hypotheses in the National Alzheimer???s Coordinating Center data sets (NACC data sets, n ??? 25,000, 17 minority), a data source uniquely suited for this purpose because of its large minority sample, the availability of survival and neuropathological data, and information on markers of AD severity. Identifying whether a survival difference exists and   potentially examining the underlying causes of this racial disparity is important, because it will be the first step towards eliminating the disparity in the future.